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In a compounded formulation that might sit in your refrigerator for weeks, stability of the ingredients matters enormously

Furthermore, more direct pathological damage occurs locally within the testes: inflammatory factors (especially TNF-) can induce the endocytosis and desensitization of FSH receptors, resulting in a marked decrease in the biological responsiveness of testicular tissue to FSH, generating typical peripheral resistance (135, 136)

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10.1016/j.bioorg.2004.06.005 61 RabahiF.BrlS.SiroisJ.BeckersJ

Higher temps pose greater risk of scald 140 is used to kill bacteria, most residential water heater thermostats have high temp range 150, while some commercial tanks can deliver 180